| Title： | Expert Consensus on the Application of Whole Genome Sequencing (WGS) in Monitoring the Transmission of Mycobacterium tuberculosis |
| Edition： | Original |
| Classification： | Others |
| Field： | Prevention |
| Countries and regions： | China |
| Guidelines users： | |
| Evidence classification method： | This consensus is general guidance without specific evidence grading. |
| Development unit： | Zhejiang Provincial Center for Disease Control and Prevention,Zhejiang Antituberculosis Association |
| Registration time: | 2024-10-24 |
| Registration number： | PREPARE-2024CN912 |
| Purpose of the guideline: | The incidence of tuberculosis (TB) remains high in China, and the situation of cluster outbreaks is critical. Due to the high homology of dominant MTB strains in China，it is difficult to accurately identify MTBs of different types or at different stages of evolution using traditional assays. This limits MTB transmission monitoring and traceability efforts. Whole genome sequencing (WGS) can accurately characterize the process, sequence of MTB transmission, and transmission source number of MTB. Providing scientific and precise interventions for the prevention and control of TB cluster outbreaks. To further standardize the application of WGS in MTB transmission monitoring, the Zhejiang Provincial Center for Disease Control and Prevention and Zhejiang Antituberculosis Association organized relevant experts to formulate this expert consensus. |
