ECMO辅助高危TAVI围术期技术要点专家共识

标题: ECMO辅助高危TAVI围术期技术要点专家共识
title: Expert consensus on perioperative technical points of ECMO assisted high-risk TAVI
版本: 原创版
version: Original
分类: 专家共识
classification: Experts consensus
领域: 综合
field: Comprehensive guideline
国家和地区: 中国
Country and region: China
指南使用者: 急诊科、重症医学科、心脏内科、心外科、麻醉科、体外循环科等TAVI团队人员
Guide users: TAVI team members from emergency department, severe medicine department, cardiology department, cardiac surgery department, anesthesia department, extracorporeal circulation department, etc
证据分级方法: 共识会议以及专家投票
Evidence grading method: Consensus meetings and expert votes
制定单位: 中华医学会急诊医学分会;山东省医学会急诊医学分会;山东省医学会心肺复苏与体外生命支持多学科联合委员会
Formulating unit: Emergency Medicine Branch of Chinese Medical Association;Emergency Medicine Branch of Shandong Medical Association;Multidisciplinary Joint Committee of Cardiopulmonary Resuscitation and In Vitro Life Support, Shandong Medical Association
注册时间: 2022-12-04
Registration time:
注册编号: PREPARE-2022CN793
Registration number:
指南制订的目的: 尽管TAVI可以作为体弱高风险主动脉瓣狭窄的无创性首选替代治疗,但其手术操作复杂,并且在围术期间可能出现许多手术相关的并发症,比如脑梗死、冠状动脉阻塞、急性肾功能衰竭和传导阻滞血流动力学紊乱等。患者薄弱身体条件加上新出现并发症可能会使病情进一步恶化,大大减少了生存率,我们迫切需要一种新的方法对高危TAVI围手术期的患者进行辅助支持治疗,改善预后并提高患者生存率。体外膜肺氧合(extracorporeal membrane oxygenation, ECMO)是一种重要的体外生命支持技术,通过完全代替或者部分代替心肺功能进行循环支持,能纠正血流动力学紊乱,改善组织灌注,从而为病人争取治疗时间。ECMO临床上主要用于心功能衰竭和(或)肺功能衰竭患者的支持治疗,已在心源性休克和高危经皮冠状动脉介入治疗患者中得到不同程度的应用。随着ECMO的普及,2020年以来国内外中心尝试在高危TAVI患者围手术期间应用ECMO,并且取得了不错的效果。静脉-动脉( venous-arterial,V-A) ECMO 特别适用于危及生命TAVI相关的急诊病例,如心脏压塞、严重瓣膜 反流、心源性休克、主动脉瓣环破裂、室性心律失常、 冠状动脉阻塞、瓣膜假体移位及持续性心肌收缩力受损等。预防性使用V-A ECMO也被用于高危TAVI病例中,可以维持血流动力学的稳定并且减轻心脏负担,很大程度上改善了患者的预后。不论是TAVI术前支持治疗还是术中发生呼吸心跳骤停ECMO都发挥重要作用。但目前对于ECMO支持高危TAVI患者围术期的治疗只是处于尝试阶段,只有少数病例报道,技术要点尚不明确,并未形成系统的专家共识。为此,由山东大学齐鲁医院牵头,共同制订了《ECMO辅助高危TAVI围术期技术要点专家共识》,旨在总结并规范在高危TAVI期间ECMO的应用,并为进一步开展临床实践和相关研究提供指导意见,以期提高我国ECMO支持下TAVI患者的存活率,改善患者的预后并且提高生活质量。
Purpose of the guideline: Although TAVI can be used as the first non-invasive alternative treatment for weak and high-risk aortic stenosis, its operation is complex, and many surgical related complications may occur during the perioperative period, such as cerebral infarction, coronary artery occlusion, acute renal failure and conduction obstruction hemodynamic disorder. The patient's weak physical condition and new complications may further worsen the condition and greatly reduce the survival rate. We urgently need a new method to provide auxiliary support treatment for high-risk TAVI patients in the perioperative period, improve the prognosis and improve the survival rate of patients. Extracorporeal membrane oxygenation (ECMO) is an important extracorporeal life support technology. It can correct hemodynamic disorders, improve tissue perfusion, and strive for treatment time for patients by completely replacing or partially replacing cardiopulmonary function for circulatory support. ECMO is mainly used for supporting treatment of patients with heart failure and/or pulmonary failure clinically, and has been applied to varying degrees in patients with cardiogenic shock and high-risk percutaneous coronary intervention. With the popularization of ECMO, since 2020, centers at home and abroad have tried to apply ECMO to high-risk TAVI patients during perioperative period, and achieved good results. Venous artery (V-A) ECMO is especially suitable for emergency cases related to life threatening TAVI, such as cardiac tamponade, severe valve regurgitation, cardiogenic shock, aortic annulus rupture, ventricular arrhythmia, coronary artery occlusion, valve prosthesis displacement and sustained myocardial contractility impairment. The prophylactic use of V-A ECMO is also used in high-risk TAVI cases, which can maintain the stability of hemodynamics and reduce the burden on the heart, and greatly improve the prognosis of patients. ECMO plays an important role in both the preoperative supportive treatment of TAVI and the occurrence of respiratory and cardiac arrest during operation. However, at present, the perioperative treatment of high-risk TAVI patients supported by ECMO is only in the trial stage, only a few cases are reported, the technical points are not clear, and no systematic expert consensus has been formed. For this reason, Qilu Hospital of Shandong University took the lead to jointly formulate the Expert Consensus on Perioperative Technical Essentials of ECMO Assisting High Risk TAVI, aiming to summarize and standardize the application of ECMO during high-risk TAVI, and provide guidance for further clinical practice and related research, so as to improve the survival rate of TAVI patients supported by ECMO in China, improve the prognosis of patients and improve the quality of life.