| Title： | Chinese Clinical Practice Guidelines for the Device Therapy of Adult Post-Cardiac Arrest Syndrome |
| Edition： | Original |
| Classification： | Standard guideline |
| Field： | Treatment |
| Countries and regions： | China |
| Guidelines users： | Medical care personnel of Emergency Department, Critical Care Units, Respiratory and Critical Care Department, Cardiology Department and Cardiac Surgery Department, general medicine practitioners, researchers and teaching staff working on the treatment of PCAS. |
| Evidence classification method： | GRADE |
| Development unit： | Taskforce of Chinese Clinical Practice Guidelines for the Device Therapy of Adult Post-Cardiac Arrest Syndrome |
| Registration time: | 2022-06-08 |
| Registration number： | IPGRP-2022CN318 |
| Purpose of the guideline: | Post-cardiac arrest syndrome (PCAS) is a syndrome of multiple organ dysfunction after the return of spontaneous circulation (ROSC), mainly caused by the reperfusion injury and eruption of inflammation factors after systematic ischemia and hypoxia during cardiac arrest (CA). In China, the incidence of CA is about 40.7 (95%CI: 38.1~ 43.3) per 100,000, only with an overall resuscitation rate of 4.0%. Among patients with out-of-hospital cardiac arrest (OHCA), the survival rate at discharge is barely 1%. PCAS is closely related to the prognosis of CA patients and is an independent risk factor for the survival rate of resuscitation. Increasing evidence suggests that efficient interventions after ROSC can significantly improve the survival rate and neurological prognosis of PCAS patients.2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care updated a fifth key link to the chain of survival, namely the comprehensive treatment after cardiopulmonary resuscitation, which proposed therapeutic management for PCAS, such as improving organ perfusion, treating primary diseases and preventing recurrent cardiac arrest. 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care also emphasized that post-resuscitation treatment is an important component of the chain of survival, suggesting comprehensive, structured and multidisciplinary cooperation for optimal treatment of PCAS. European Resuscitation Council and European Society of Intensive Care Medicine updated guidelines on post-resuscitation care in 2021, based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. To guide and standardize the usage of device therapy in adult PCAS patients in China, evidence-based clinical practice guidelines are needed for post-resuscitation care and clinical decisions. |
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