| 标题： | 多聚脱氧核糖核苷酸在皮肤科的临床应用专家共识(2024版) |
| title： | Expert consensus on the use of polydeoxyribonucleotide in dermatology（2024） |
| 版本： | 原创版 |
| version： | Original |
| 分类： | 专家共识 |
| classification： | Experts consensus |
| 领域： | 综合 |
| field： | Comprehensive guideline |
| 国家和地区： | 中国 |
| Country and region： | China |
| 指南使用者： | 使用者为临床医师、营养医师、护理人员、健康管理师等专业人员。 |
| Guide users： | Users are clinicians, dietitians, caregivers, health managers and other professionals. |
| 证据分级方法： | GRADE证据分级 |
| Evidence grading method： | GRADE Evidence Grading |
| 制定单位： | 陆军军医大学西南医院皮肤科 |
| Formulating unit： | Department of Dermatology, Southwest Hospital, Army Medical University (Third Military Medical University) |
| 注册时间： | 2024-01-23 |
| Registration time： | |
| 注册编号： | PREPARE-2024CN204 |
| Registration number： | |
| 指南制订的目的： | 多聚脱氧核糖核苷酸（Polydeoxyribonucleotide, PDRN）是由多核苷酸混合物组成的DNA衍生物，PDRN可通过激活腺苷A2A受体或“补救途径”两种机制，发挥抗炎、抗凋亡、抗黑素生成、促进胶原再生及血管生成等效应。近年来，已应用在皮肤科尤其是皮肤美容领域。为规范PDRN在皮肤中的应用，PDRN临床应用共识专家组结合国内外最新研究进展，在广泛讨论基础上制订本共识，从PDRN的作用机制，适应症和安全性等方面，为临床应用提供指导建议。 |
| Purpose of the guideline： | Polydeoxyribonucleotide (PDRN) is a DNA derivative composed of a mixture of polynucleotides. PDRN exerts anti-inflammatory, anti-apoptotic, anti-melanogenic, collagen regeneration and angiogenic effects through activation of the adenosine A2A receptor or the “salvage pathway.” In recent years, PDRN has been extensively utilized in dermatology, particularly in the field of cosmetic dermatology. To ensure uniformity in its application, the PDRN Clinical Application Consensus Expert Group has meticulously developed a consensus document based on extensive discussions and the latest research findings from both domestic and international sources. The document aims to provide practitioners with clear guidance and recommendations on the clinical application of PDRN, including its mechanism of action, effectiveness, safety, indications, and contraindications. |
