At present, the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) dominate the publication of international guidelines of ankylosing spondylitis (AS). These guidelines provide authoritative recommendations for medical staffs around the world and are updated every 2-3 years. In China, the guidelines for diagnosis and treatment of rheumatic diseases are mainly formulated by Chinese Rheumatology Association of Chinese Medical Association. Combined with the characteristics of Chinese patients，the guidelines published by ACR and EULAR was revised by the Chinese Rheumatology Association so as to make the guidelines more in line with the actual situati -on in China. However, the Association had not updated the guideline since the Chinese Journal of Rheumatology published a guideline for the diagnosis and treatment of ankylosing spondylitis in 2010. Moreover, there was no guideline for the diagnosis and treatment of ankylosing spondylitis with integrated traditional Chinese and Western Medicine at home and abroad in recent 10 years, which has become a major obstacle to the standardized diagnosis and treatment of ankylosing spondylitis in China. Finally, Rheumatology is too young for other subjects, and the level of doctors from the grass-roots unit are uneven. Most of them rely personal experiences more than on guidelines to diagnose and treat AS, which lead to many misdiagnosis and the unsatisfied curative effects . It is urgent for us to formulate a guideline to standardize their clinical diagnosis and treatment of AS. To sum up, based on the latest research evidence and the clinical practice in China, we will formulate a guideline in accordance with the authoritative guidelines for developing guidelines,.