| Title： | Guidelines for the needle synovial biopsy: recommendations for standardization and clinical practice |
| Edition： | Original |
| Classification： | Experts consensus |
| Field： | Diagnosis |
| Countries and regions： | China |
| Guidelines users： | Rheumatology, Orthopedics, Rehabilitation, Pain Medicine and other clinical staff, pathologists and related medical researchers. |
| Evidence classification method： | 1. GRADE System (Grading of Recommendations Assessment, Development, and Evaluation) Evidence Quality Grading**: - High Quality Further research is unlikely to change the confidence in the estimate of effect. - Moderate Quality Further research may have a significant impact on the confidence in the estimate of effect and may change the estimate. - Low Quality Further research is very likely to have a significant impact on the confidence in the estimate of effect and may change the current estimate. - Very Low Quality: Confidence in the estimate of effect is very limited, and further research is almost certain to affect the current estimate. Recommendation Strength Grading - Strong Recommendation: A clear recommendation to adopt the intervention, based on high-quality evidence. - Weak Recommendation: A suggestion to consider the intervention, based on lower quality evidence or after balancing different interests, indicating that the intervention should be applied flexibly depending on the specific situation. 2. AGREE II Tool (Appraisal of Guidelines for Research & Evaluation II) The AGREE II tool is mainly used to evaluate the guideline development process, aiming to ensure systematic and transparent development. Although this tool does not directly grade the evidence, it provides important assurance for the rationality of evidence grading and the scientific nature of guideline recommendations, ensuring the rigor and credibility of guideline development. |
| Development unit： | The First Affiliated Hospital of Nanchang University |
| Registration time: | 2024-09-09 |
| Registration number： | PREPARE-2024CN444 |
| Purpose of the guideline: | The purpose of this guideline is to provide practical advice on the optimization and standardization of synovial biopsy techniques, the handling and quality control of synovial tissue and the clinical application of synovial biopsy for rheumatology, orthopaedics, rehabilitation, pain medicine and other clinicians, pathologists and related medical researchers, aiming to standardize the application of needle synovial biopsy and pathological analysis in the diagnosis and treatment of joint diseases and to improve the level of diagnosis and treatment of joint diseases. |
