Consensus on clinical management of tumor-induced osteomalacia

Title: Consensus on clinical management of tumor-induced osteomalacia
Edition: Original
Classification: Experts consensus
Field: Diagnosis and Treatment
Countries and regions: China
Guidelines users: Health practitioners, endocrinologists, orthopedists, rheumatology immunologists
Evidence classification method: We provided recommendations based on an expert review of the limited data, as well as their experiences and opinions when data was unavailable. An scientific grading system was not applicable since high quality evidence was scarce in this field.
Development unit: Chinese Society of Osteoporosis and Bone Mineral Research, Chinese Society of Endocrinology
Registration time: 2021-01-29
Registration number: IPGRP-2021CN023
Purpose of the guideline: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23 (FGF23) production by a tumor which often arises from a mesenchymal origin. Most clinical symptoms of TIO are the consequences of prolonged FGF23- mediated hypophosphatemia as muscle weakness, bone pain, impaired mobility and fractures. Clinical diagnosis and management of TIO is challenging, but knowledge of this condition is still restricted to a few specialized centers, leading to delay of diagnosis and appropriate treatment. The scope of the present consensus is to provide an up-to-date guidance on the assessment and treatment of TIO.